Bacterial Resistant Mattresses

Explore Bacterial Resistant Mattresses at Mattress Firm to find options that fit your sleep preferences, space and budget. Compare available sizes, styles and price points to make choosing your next mattress simple.

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Sleepy's Signature TOTAL DEFENSE Mattress Protector

5687

Starting at

$99⁹⁹

Temperature
Allergies

Save $100 when you bundle¹⁰.

Sleepy's Deluxe Comfort Cool Mattress Protector

4179

Starting at

$129⁹⁹

Temperature
Allergies

Save $150 when you bundle¹⁰.

Sleepy's Signature Total Encasement Mattress Protector

1001

Starting at

$159⁹⁹

Temperature

Beautyrest Silver BRS900 11.75" Extra Firm Mattress

3296

Starting at

$579⁹⁹

$1399⁹⁹

$820 OFF

Extra Firm Comfort, best for

Back, Stomach Sleepers
Temperature
Pain
Allergies
Bed Partner
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beautyrest BR800 11.25" Firm Mattress

2233

Starting at

$619⁹⁹

$1299⁹⁹

$680 OFF

Firm Comfort, best for

Back, Stomach Sleepers
Toss and Turn
Pain
Bed Partner
Temperature

FREE ADJUSTABLE BASE ³ with code ELEVATE

Sleepy's 3" Gel Memory Foam Mattress Topper

396

Starting at

$99⁹⁹

$149⁹⁹

$50 OFF

Medium Comfort,

Temperature

Tulo Bamboo 10" Medium Green Tea Memory Foam Mattress

5555

Starting at

$379⁹⁹

$889⁹⁹

$510 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Bed Partner
Temperature
Allergies
Toss and Turn

Tulo Bamboo 12" Medium Plush Green Tea Memory Foam Mattress

5555

Starting at

$329⁹⁹

$789⁹⁹

$460 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Bed Partner
Pain
Temperature
Toss and Turn

Beautyrest BR800 13.5" Medium Pillow Top Mattress

1863

Starting at

$819⁹⁹

$1499⁹⁹

$680 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Toss and Turn
Pain
Bed Partner
Temperature

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beautyrest Silver BRS900-C 13.75" Extra Firm Mattress

1810

Starting at

$859⁹⁹

$1999⁹⁹

$1140 OFF

Extra Firm Comfort, best for

Back, Stomach Sleepers
Temperature
Pain
Bed Partner
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Tulo Bamboo 8" Medium Green Tea Memory Foam Mattress

5555

Starting at

$329⁹⁹

$809⁹⁹

$480 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

Beautyrest Silver BRS900 11.75" Medium Firm Mattress

1745

Starting at

$809⁹⁹

$1099⁹⁹

$290 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Allergies
Bed Partner
Temperature
Pain
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beautyrest BR800 12" Plush Euro Top Mattress

735

Starting at

$569⁹⁹

$1399⁹⁹

$830 OFF

Plush Comfort, best for

Side Sleepers
Toss and Turn
Pain
Bed Partner
Temperature

Tulo Lavender 6" Firm Memory Foam Mattress

217

Starting at

$319⁹⁹

Firm Comfort, best for

Back, Stomach Sleepers
Temperature
Pain
Bed Partner
Allergies
Toss and Turn

Tulo Bamboo 6" Firm Green Tea Memory Foam Mattress

5558

Starting at

$729⁹⁹

Firm Comfort, best for

Back, Stomach Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beautyrest Silver BRS900 12" Plush Mattress

1140

Starting at

$549⁹⁹

$1399⁹⁹

$850 OFF

Plush Comfort, best for

Side Sleepers
Temperature
Pain
Bed Partner
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Allerease Ultimate Mattress Protector

337

Starting at

$49⁹⁹

Temperature
Allergies

Purple Restore 11.5" Soft Hybrid Mattress

1662

Starting at

$1830⁰⁰

$2299⁰⁰

$469 OFF

Plush Comfort, best for

Side Sleepers
Pain
Allergies
Bed Partner
Toss and Turn
Temperature

Purple RestorePlus Cool Touch 13" Hybrid Mattress

997

Starting at

$3900⁰⁰

$4699⁰⁰

$799 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Allergies
Bed Partner
Toss and Turn

$300 ^◇ adjustable base instant gift with purchase.

Beautyrest Silver BRS900-C 14.5" Medium Mattress

791

Starting at

$859⁹⁹

$1999⁹⁹

$1140 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Temperature
Pain
Bed Partner
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Purple Restore Cool Touch 11.5" Hybrid Mattress

782

Starting at

$3000⁰⁰

$3699⁰⁰

$699 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

$300 ^◇ adjustable base instant gift with purchase.

Beautyrest BR800 Greenwood 10.5" Firm Mattress

3404

Starting at

$1299⁹⁹

Firm Comfort, best for

Back, Stomach Sleepers
Bed Partner
Toss and Turn
Temperature
Pain

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beautyrest BR800 11.5" Medium Firm Mattress

3145

Starting at

$459⁹⁹

$999⁹⁹

$540 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Toss and Turn
Pain
Bed Partner
Temperature

Purple Restore 11.5" Firm Hybrid Mattress

843

Starting at

$2700⁰⁰

$3399⁰⁰

$699 OFF

Firm Comfort, best for

Back, Stomach Sleepers
Pain
Allergies
Bed Partner
Toss and Turn
Temperature

Kingsdown Crown Imperial 16" Firm Euro Top Mattress

125

Starting at

$4399⁰⁰

$5799⁰⁰

$1400 OFF

Firm Comfort, best for

Back, Stomach Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Kingsdown Crown Imperial 15" Firm Mattress

Starting at

$3399⁰⁰

$4499⁰⁰

$1100 OFF

Firm Comfort, best for

Back, Stomach Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Bacterial resistant mattresses are designed with materials and covers that help limit the growth and buildup of certain bacteria on the sleep surface, making them an appealing option for shoppers who prioritize a cleaner, fresher bed. Antimicrobial mattress fabrics, moisture-wicking covers and breathable comfort layers can help manage sweat and humidity, two factors that may contribute to odor and microbial growth. Some mattresses use treated textiles or naturally resistant fibers, while others pair a supportive mattress with an antimicrobial mattress protector for an added layer of coverage. Because features vary by model, review the product details to understand whether a mattress offers bacterial-resistant materials, an antimicrobial cover or simply breathable construction designed to promote a drier sleep environment. A bacterial resistant mattress still benefits from regular care and proper bedroom hygiene. Use a well-fitting, washable mattress protector, launder sheets and bedding according to the manufacturer’s instructions, and allow the mattress to air out during routine cleaning. Vacuuming the mattress surface with an appropriate upholstery attachment can help remove dust and debris, while keeping the bedroom cool and well ventilated may help reduce excess moisture. Mattress protectors should never replace cleaning, and no mattress can eliminate all bacteria or guarantee a germ-free sleep surface. Choosing a breathable mattress with a removable or washable cover, following care guidelines and replacing bedding regularly can support a fresher, more comfortable place to rest and help you get better zzz's.

What materials are commonly used in bacterial resistant mattresses + -

These mattresses may feature treated covers, antimicrobial fibers or foams, and moisture-managing materials. Check each mattress description for details about its materials and construction.

How do bacterial resistant mattresses differ in construction + -

They may include specialized cover fabrics or comfort layers designed with bacterial-resistant properties. The exact construction varies by brand and mattress model.

Can I use regular bedding with a bacterial resistant mattress + -

Yes, standard sheets, mattress pads and other compatible bedding can generally be used. Choose bedding that fits the mattress profile and follow the care instructions for both the mattress and accessories.

How should I care for a bacterial resistant mattress + -

Use a supportive foundation, rotate the mattress if the manufacturer recommends it and keep the cover clean according to its care label. Avoid removing or washing the mattress cover unless the instructions specifically allow it.

What should I look for when choosing a bacterial resistant mattress + -

Compare the cover fabric, comfort materials, support system and care requirements. You can also consider your preferred firmness, sleeping position and mattress feel to find an option that suits your routine.