Queen Hybrid Mattresses With Antimicrobial Finish

Explore Queen Hybrid Mattresses With Antimicrobial Finish at Mattress Firm to find a queen-size sleep surface that aligns with your comfort preferences, support needs and bedroom setup. Compare available options and shop for the mattress that helps make sleep easy™.

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Beautyrest Silver BRS900 11.75" Extra Firm Mattress

3302

Starting at

$579⁹⁹

$1399⁹⁹

$820 OFF

Extra Firm Comfort, best for

Back, Stomach Sleepers
Temperature
Pain
Allergies
Bed Partner
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beautyrest BR800 11.25" Firm Mattress

2239

Starting at

$489⁹⁹

$999⁹⁹

$510 OFF

Firm Comfort, best for

Back, Stomach Sleepers
Toss and Turn
Pain
Bed Partner
Temperature

FREE ADJUSTABLE BASE ³ with code ELEVATE

Tulo Bamboo 12" Medium Plush Green Tea Memory Foam Mattress

5567

Starting at

$369⁹⁹

$869⁹⁹

$500 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Bed Partner
Pain
Temperature
Toss and Turn

Beautyrest BR800 13.5" Medium Pillow Top Mattress

1868

Starting at

$609⁹⁹

$1219⁹⁹

$610 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Toss and Turn
Pain
Bed Partner
Temperature

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beautyrest Silver BRS900-C 13.75" Extra Firm Mattress

1816

Starting at

$679⁹⁹

$1599⁹⁹

$920 OFF

Extra Firm Comfort, best for

Back, Stomach Sleepers
Temperature
Pain
Bed Partner
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beautyrest Silver BRS900 11.75" Medium Firm Mattress

1749

Starting at

$659⁹⁹

$899⁹⁹

$240 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Allergies
Bed Partner
Temperature
Pain
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beautyrest BR800 12" Plush Euro Top Mattress

739

Starting at

$469⁹⁹

$1099⁹⁹

$630 OFF

Plush Comfort, best for

Side Sleepers
Toss and Turn
Pain
Bed Partner
Temperature

Beautyrest Silver BRS900 12" Plush Mattress

1147

Starting at

$579⁹⁹

$1359⁹⁹

$780 OFF

Plush Comfort, best for

Side Sleepers
Temperature
Pain
Bed Partner
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Purple RestorePlus 13" Soft Hybrid Mattress

3534

Starting at

$2940⁰⁰

$3599⁰⁰

$659 OFF

Plush Comfort, best for

Side Sleepers
Pain
Allergies
Bed Partner
Toss and Turn
Temperature

Purple Restore 11.5" Soft Hybrid Mattress

1666

Starting at

$2140⁰⁰

$2699⁰⁰

$559 OFF

Plush Comfort, best for

Side Sleepers
Pain
Allergies
Bed Partner
Toss and Turn
Temperature

Purple RestorePlus Cool Touch 13" Hybrid Mattress

1005

Starting at

$3240⁰⁰

$3899⁰⁰

$659 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Allergies
Bed Partner
Toss and Turn

$300 ^◇ adjustable base instant gift with purchase.

Purple RestorePremier Cool Touch 13" Hybrid Mattress

856

Starting at

$4020⁰⁰

$4699⁰⁰

$679 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Allergies
Bed Partner
Toss and Turn

$300 ^◇ adjustable base instant gift with purchase.

Beautyrest Silver BRS900-C 14.5" Medium Mattress

795

Starting at

$679⁹⁹

$1599⁹⁹

$920 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Temperature
Pain
Bed Partner
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Purple Restore Cool Touch 11.5" Hybrid Mattress

790

Starting at

$2440⁰⁰

$2999⁰⁰

$559 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

$300 ^◇ adjustable base instant gift with purchase.

Beautyrest BR800 11.5" Medium Firm Mattress

3152

Starting at

$459⁹⁹

$999⁹⁹

$540 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Toss and Turn
Pain
Bed Partner
Temperature

Purple Restore 11.5" Firm Hybrid Mattress

843

Starting at

$2140⁰⁰

$2699⁰⁰

$559 OFF

Firm Comfort, best for

Back, Stomach Sleepers
Pain
Allergies
Bed Partner
Toss and Turn
Temperature

Kingsdown Crown Imperial 16" Plush Euro Top Mattress

172

Starting at

$4499⁰⁰

$5999⁰⁰

$1500 OFF

Plush Comfort, best for

Side Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Kingsdown Wesley 15.5" Firm Mattress

Starting at

$3399⁰⁰

$3999⁰⁰

$600 OFF

Firm Comfort, best for

Back, Stomach Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

$300 ⁶ adjustable base instant gift with purchase.

Kingsdown Wesley 15" Extra Firm Mattress

Starting at

$3399⁰⁰

$3999⁰⁰

$600 OFF

Extra Firm Comfort, best for

Back, Stomach Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

$300 ⁶ adjustable base instant gift with purchase.

Sleepy's Signature TOTAL DEFENSE Mattress Protector

5735

Starting at

$99⁹⁹

Temperature
Allergies

Save $100 when you bundle¹⁰.

Beautyrest PressureSmart 2.0 Hybrid Medium 13" Mattress

1758

Starting at

$1125⁰⁰

$2249⁹⁹

$1125 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Bed Partner
Temperature
Allergies
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Sleepy's 3" Gel Memory Foam Mattress Topper

398

Starting at

$199⁹⁹

Medium Comfort,

Temperature

Tulo Bamboo 10" Medium Green Tea Memory Foam Mattress

5567

Starting at

$329⁹⁹

$789⁹⁹

$460 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Bed Partner
Temperature
Allergies
Toss and Turn

Tulo Bamboo 8" Medium Green Tea Memory Foam Mattress

5567

Starting at

$279⁹⁹

$689⁹⁹

$410 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

Sleepy's 4" Reversible Gel Memory Foam Topper

Starting at

$169⁹⁹

$249⁹⁹

$80 OFF

Medium Comfort,

Temperature
Allergies

Tempur-Pedic TEMPUR-Adapt + Cooling Mattress Topper

4657

Starting at

$439⁰⁰

Medium Comfort,

Temperature
Allergies

A queen hybrid mattress with an antimicrobial finish combines the pressure-relieving comfort of foam with the responsive support of individually wrapped coils. The antimicrobial finish is designed to help inhibit the growth of odor-causing bacteria on the mattress surface, while breathable fabrics and a ventilated comfort system can promote airflow throughout the night. This combination makes a queen hybrid mattress a practical choice for couples, guest rooms and primary bedrooms, offering ample sleeping space without taking up as much room as a king mattress. Depending on the model, shoppers can choose from memory foam hybrid mattresses for contouring comfort, latex hybrid mattresses for buoyant support or pillow-top hybrid designs for an extra layer of cushioning. Choosing the best queen hybrid mattress with an antimicrobial finish starts with comparing firmness, materials, temperature regulation and support. A medium-firm queen hybrid mattress may help balance cushioning and stability for a wide range of sleepers, while a plush hybrid mattress can provide a softer feel for those who prefer deeper pressure relief. Individually wrapped innerspring coils help reduce motion transfer and reinforce the mattress edges, and targeted support zones may encourage more balanced alignment. Look for breathable mattress covers, cooling foams and moisture-managing fabrics if you tend to sleep warm, and remember that an antimicrobial finish does not replace regular mattress care. Use a supportive foundation, protect the surface with a compatible mattress protector and follow the manufacturer’s cleaning instructions to help keep your queen hybrid mattress feeling fresh and comfortable.

What is a hybrid mattress with an antimicrobial finish? + -

A hybrid mattress combines individually wrapped coils with comfort layers such as memory foam, latex or other foams. An antimicrobial finish is applied to select materials or fabric surfaces as part of the mattress design.

How does a hybrid mattress feel? + -

Hybrid mattresses typically offer a balance of responsive support from coils and pressure-relieving comfort from foam or other cushioning materials. The feel can range from plush to firm depending on the comfort layers and overall design.

What comfort materials are used in hybrid mattresses? + -

Common comfort materials include memory foam, gel-infused foam, latex and quilted fiber layers. Each material can contribute a different combination of cushioning, responsiveness and surface comfort.

How should I care for a hybrid mattress with an antimicrobial finish? + -

Use a breathable mattress protector, rotate the mattress according to the manufacturer’s care instructions and keep the surface free of moisture. Avoid applying household cleaning products directly to the mattress unless the care instructions specifically allow it.

What bed frames work with hybrid mattresses? + -

Hybrid mattresses are compatible with many supportive foundations, platform beds and adjustable bases. Choose a sturdy foundation with the appropriate spacing and weight support for the mattress, and follow the manufacturer’s recommendations.