Plush Antimicrobial Mattresses

Explore Plush Antimicrobial Mattresses at Mattress Firm to find a comfortable sleep solution that suits your preferred feel, size and budget. Shop online or visit a store to compare options and make it easier to choose a mattress for better zzz's.

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Beautyrest PressureSmart 2.0 Plush 11.75" Mattress

6251

Starting at

$724⁹⁹

$1449⁹⁹

$725 OFF

Plush Comfort, best for

Side Sleepers
Temperature
Bed Partner
Pain
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beautyrest BR800 11.25" Firm Mattress

2233

Starting at

$489⁹⁹

$999⁹⁹

$510 OFF

Firm Comfort, best for

Back, Stomach Sleepers
Toss and Turn
Pain
Bed Partner
Temperature

FREE ADJUSTABLE BASE ³ with code ELEVATE

Tulo Bamboo 10" Medium Green Tea Memory Foam Mattress

5555

Starting at

$379⁹⁹

$889⁹⁹

$510 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Bed Partner
Temperature
Allergies
Toss and Turn

Tulo Bamboo 12" Medium Plush Green Tea Memory Foam Mattress

5555

Starting at

$329⁹⁹

$789⁹⁹

$460 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Bed Partner
Pain
Temperature
Toss and Turn

Beautyrest BR800 13.5" Medium Pillow Top Mattress

1863

Starting at

$609⁹⁹

$1219⁹⁹

$610 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Toss and Turn
Pain
Bed Partner
Temperature

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beautyrest Silver BRS900-C 13.75" Extra Firm Mattress

1810

Starting at

$859⁹⁹

$1999⁹⁹

$1140 OFF

Extra Firm Comfort, best for

Back, Stomach Sleepers
Temperature
Pain
Bed Partner
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Tulo Bamboo 8" Medium Green Tea Memory Foam Mattress

5555

Starting at

$249⁹⁹

$609⁹⁹

$360 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

Beautyrest Silver BRS900 11.75" Medium Firm Mattress

1745

Starting at

$669⁹⁹

$849⁹⁹

$180 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Allergies
Bed Partner
Temperature
Pain
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beautyrest BR800 12" Plush Euro Top Mattress

735

Starting at

$429⁹⁹

$1099⁹⁹

$670 OFF

Plush Comfort, best for

Side Sleepers
Toss and Turn
Pain
Bed Partner
Temperature

Beautyrest Silver BRS900 12" Plush Mattress

1140

Starting at

$729⁹⁹

$1699⁹⁹

$970 OFF

Plush Comfort, best for

Side Sleepers
Temperature
Pain
Bed Partner
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Nectar Premier 13" Medium Memory Foam Mattress

486

Starting at

$1099⁰⁰

$1799⁰⁰

$700 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

Sleepy's 4" Reversible Gel Memory Foam Topper

Starting at

$199⁹⁹

$299⁹⁹

$100 OFF

Medium Comfort,

Temperature
Allergies

Beautyrest Black Series Two 16.25" Plush Pillow Top Mattress

292

Starting at

$2829⁰⁰

$3229⁰⁰

$400 OFF

Plush Comfort, best for

Side Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

$300 ⁶ adjustable base instant gift with purchase.

Tempur-Pedic TEMPUR-ProAdapt 2.0 12" Soft Mattress

3494

Starting at

$3799⁰⁰

$4199⁰⁰

$400 OFF

Plush Comfort, best for

Side Sleepers
Pain
Allergies
Bed Partner
Toss and Turn
Temperature

Receive $300 Instant Gift⁴ with purchase + Calm app 3-month free trial

Purple Restore 11.5" Soft Hybrid Mattress

1662

Starting at

$2700⁰⁰

$3399⁰⁰

$699 OFF

Plush Comfort, best for

Side Sleepers
Pain
Allergies
Bed Partner
Toss and Turn
Temperature

Purple RestorePlus Cool Touch 13" Hybrid Mattress

997

Starting at

$2840⁰⁰

$3399⁰⁰

$559 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Allergies
Bed Partner
Toss and Turn

$300 ^◇ adjustable base instant gift with purchase.

Beautyrest Silver BRS900-C 14.5" Medium Mattress

791

Starting at

$599⁹⁹

$1399⁹⁹

$800 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Temperature
Pain
Bed Partner
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Purple Restore Cool Touch 11.5" Hybrid Mattress

782

Starting at

$2130⁰⁰

$2599⁰⁰

$469 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

$300 ^◇ adjustable base instant gift with purchase.

Sealy Essentials Autumn Ash 10.5" Plush Mattress

Starting at

$444⁹⁹

$799⁹⁹

$355 OFF

Plush Comfort, best for

Side Sleepers
Pain
Temperature
Bed Partner
Toss and Turn
Allergies

Beautyrest BR800 Greenwood 10.5" Firm Mattress

3404

Starting at

$899⁹⁹

Firm Comfort, best for

Back, Stomach Sleepers
Bed Partner
Toss and Turn
Temperature
Pain

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beautyrest BR800 11.5" Medium Firm Mattress

3145

Starting at

$439⁹⁹

$959⁹⁹

$520 OFF

Medium Comfort, best for

Back, Side, Stomach Sleepers
Toss and Turn
Pain
Bed Partner
Temperature

Purple Restore 11.5" Firm Hybrid Mattress

843

Starting at

$2700⁰⁰

$3399⁰⁰

$699 OFF

Firm Comfort, best for

Back, Stomach Sleepers
Pain
Allergies
Bed Partner
Toss and Turn
Temperature

Kingsdown Crown Imperial 16" Plush Euro Top Mattress

167

Starting at

$5999⁰⁰

Plush Comfort, best for

Side Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Kingsdown Crown Imperial 16" Firm Euro Top Mattress

125

Starting at

$3899⁰⁰

$5199⁰⁰

$1300 OFF

Firm Comfort, best for

Back, Stomach Sleepers
Pain
Bed Partner
Temperature
Toss and Turn

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beauty Sleep® Midnight Dream 13.75" Plush Mattress

102

Starting at

$669⁹⁹

$1449⁹⁹

$780 OFF

Plush Comfort, best for

Side Sleepers
Toss and Turn
Bed Partner
Temperature
Pain

FREE ADJUSTABLE BASE ³ with code ELEVATE

Beauty Sleep® Midnight Dream II 13.75" Plush Mattress

Starting at

$669⁹⁹

$1449⁹⁹

$780 OFF

Plush Comfort, best for

Side Sleepers
Toss and Turn
Bed Partner
Temperature
Pain

FREE ADJUSTABLE BASE ³ with code ELEVATE

A plush antimicrobial mattress combines the pressure-relieving comfort of a soft sleep surface with materials designed to help inhibit the growth of odor-causing bacteria and microbes. With layers such as quilted memory foam, responsive comfort foam and breathable fibers, these mattresses provide a cushioned feel that gently conforms to the body while helping support a cleaner, fresher sleep environment. Antimicrobial mattress covers and treated fabrics may be especially appealing for sleepers who want added freshness, though they do not replace regular cleaning, the use of a mattress protector or proper bedroom ventilation. Explore plush mattresses in a range of comfort levels to find the balance of softness, support and temperature regulation that suits your sleep style. The best plush antimicrobial mattress for you should provide more than a soft initial feel. Look for durable construction, targeted support and breathable materials that help reduce heat buildup throughout the night. Side sleepers may appreciate a plush mattress with pressure relief around the shoulders and hips, while combination sleepers may prefer responsive foam or individually wrapped coils for easier movement. Mattress Firm offers plush antimicrobial mattress options from trusted brands, including models with cooling covers, memory foam comfort layers and reinforced edges. Compare mattress sizes, materials and firmness levels, then use a mattress protector to help guard against spills, allergens and everyday wear while keeping your sleep space comfortable and fresh.

What is a plush antimicrobial mattress? + -

A plush antimicrobial mattress combines a softer, more cushioned feel with materials designed to help maintain a fresher sleep surface. The exact construction can vary by mattress, so review the product details to learn more about its cover, comfort layers and support system.

How does a plush antimicrobial mattress feel? + -

Plush mattresses typically feel soft and cushioned when you lie down. They may provide a more enveloping sensation than medium or firm mattresses, while the support core helps create a balanced feel.

What materials are commonly used in plush antimicrobial mattresses? + -

Plush antimicrobial mattresses may include memory foam, comfort foam, latex or individually wrapped coils, along with a specialized cover or treatment. Materials vary by model, so check each mattress description for specific details.

Who may prefer a plush antimicrobial mattress? + -

A plush antimicrobial mattress may appeal to sleepers who enjoy a softer surface and a cushioned feel. Personal comfort preferences, sleeping position and preferred level of support can help guide your selection.

How should I care for a plush antimicrobial mattress? + -

Use a compatible mattress protector, rotate the mattress according to the manufacturer's recommendations and follow the care instructions provided with your mattress. Regularly washing removable bedding can also help keep your sleep setup feeling fresh.